The Study of Efficacy of Nimodipine in Potentiation of the Anaesthetic Effect of Ketamine in Guinea Pigs
نویسنده
چکیده
Materials and Methods : 18 adult male guinea pigs of weight 400-600 grams were utilized. They were randomly divided into three groups of 6 each. First group received only Injection. Nimodipine 10 mg/kg intraperitoneally. Second group received only Inj.Ketamine 50 mg/kg i.p. Third group received Inj.Nimodipine 10 mg/kg, 30 minutes before Inj.Ketamine 50mg/kg i.p. After administration of the drug, animals are watched for its righting reflex. Induction time is the time duration from administration of the drug till the animal loses its righting reflex is noted. The duration of anesthesia(time duration from the animal loses its righting reflex till it regains the same) were noted in each group. The observations are analyzed with suitable statistical tool.
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